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(Created page with "<p> </p> <p><span class="src"><span class="jrnl" title="Nature">Nature</span>. 2008 Nov 6;456(7218):60-5.</span></p> <p> </p> <p><span class="src"> <div class="fm-title...")
 
 
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<p><span style="font-size: large">&nbsp;Nature. 2008 Nov 6;456(7218):60-5.</span></p>
 
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<p><span class="src"><span class="jrnl" title="Nature">Nature</span>. 2008 Nov 6;456(7218):60-5.</span></p>
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<p><span style="font-size: large"><br />
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The diploid genome sequence of an Asian individual</span></p>
 
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<div class="fm-title">The diploid genome sequence of an Asian individual</div>
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Jun Wang,1,2,3,4* Wei Wang,1,3* Ruiqiang Li,1,3,4* Yingrui Li,1,5,6* Geng Tian,1,7 Laurie Goodman,1 Wei Fan,1 Junqing Zhang,1 Jun Li,1 Juanbin Zhang,1 Yiran Guo,1,7 Binxiao Feng,1 Heng Li,1,8 Yao Lu,1 Xiaodong Fang,1 Huiqing Liang,1 Zhenglin Du,1 Dong Li,1 Yiqing Zhao,1,7 Yujie Hu,1,7 Zhenzhen Yang,1 Hancheng Zheng,1 Ines Hellmann,9 Michael Inouye,8 John Pool,9 Xin Yi,1,7 Jing Zhao,1 Jinjie Duan,1 Yan Zhou,1 Junjie Qin,1,7 Lijia Ma,1,7 Guoqing Li,1 Zhentao Yang,1 Guojie Zhang,1,7 Bin Yang,1 Chang Yu,1 Fang Liang,1,7 Wenjie Li,1 Shaochuan Li,1 Dawei Li,1 Peixiang Ni,1 Jue Ruan,1,7 Qibin Li,1,7 Hongmei Zhu,1 Dongyuan Liu,1 Zhike Lu,1 Ning Li,1,7 Guangwu Guo,1,7 Jianguo Zhang,1 Jia Ye,1 Lin Fang,1 Qin Hao,1,7 Quan Chen,1,5 Yu Liang,1,7 Yeyang Su,1,7 A. san,1,7 Cuo Ping,1,7 Shuang Yang,1 Fang Chen,1,7 Li Li,1 Ke Zhou,1 Hongkun Zheng,1,4 Yuanyuan Ren,1 Ling Yang,1 Yang Gao,1,6 Guohua Yang,1,2 Zhuo Li,1 Xiaoli Feng,1 Karsten Kristiansen,4 Gane Ka-Shu Wong,1,10 Rasmus Nielsen,9 Richard Durbin,8 Lars Bolund,1,11 Xiuqing Zhang,1,6 Songgang Li,1,2,5 Huanming Yang,1,2,3 and Jian Wang1,2,3<br />
<div class="contrib-group fm-author">Jun Wang,<font size="2"><sup>1,</sup><sup>2,</sup><sup>3,</sup><sup>4</sup><sup>*</sup></font> Wei Wang,<font size="2"><sup>1,</sup><sup>3</sup><sup>*</sup></font> Ruiqiang Li,<font size="2"><sup>1,</sup><sup>3,</sup><sup>4</sup><sup>*</sup></font> Yingrui Li,<font size="2"><sup>1,</sup><sup>5,</sup><sup>6</sup><sup>*</sup></font> Geng Tian,<font size="2"><sup>1,</sup><sup>7</sup></font> Laurie Goodman,<sup><font size="2">1</font></sup> Wei Fan,<sup><font size="2">1</font></sup> Junqing Zhang,<sup><font size="2">1</font></sup> Jun Li,<sup><font size="2">1</font></sup> Juanbin Zhang,<sup><font size="2">1</font></sup> Yiran Guo,<font size="2"><sup>1,</sup><sup>7</sup></font> Binxiao Feng,<sup><font size="2">1</font></sup> Heng Li,<font size="2"><sup>1,</sup><sup>8</sup></font> Yao Lu,<sup><font size="2">1</font></sup> Xiaodong Fang,<sup><font size="2">1</font></sup> Huiqing Liang,<sup><font size="2">1</font></sup> Zhenglin Du,<sup><font size="2">1</font></sup> Dong Li,<sup><font size="2">1</font></sup> Yiqing Zhao,<font size="2"><sup>1,</sup><sup>7</sup></font> Yujie Hu,<font size="2"><sup>1,</sup><sup>7</sup></font> Zhenzhen Yang,<sup><font size="2">1</font></sup> Hancheng Zheng,<sup><font size="2">1</font></sup> Ines Hellmann,<sup><font size="2">9</font></sup> Michael Inouye,<sup><font size="2">8</font></sup> John Pool,<sup><font size="2">9</font></sup> Xin Yi,<font size="2"><sup>1,</sup><sup>7</sup></font> Jing Zhao,<sup><font size="2">1</font></sup> Jinjie Duan,<sup><font size="2">1</font></sup> Yan Zhou,<sup><font size="2">1</font></sup> Junjie Qin,<font size="2"><sup>1,</sup><sup>7</sup></font> Lijia Ma,<font size="2"><sup>1,</sup><sup>7</sup></font> Guoqing Li,<sup><font size="2">1</font></sup> Zhentao Yang,<sup><font size="2">1</font></sup> Guojie Zhang,<font size="2"><sup>1,</sup><sup>7</sup></font> Bin Yang,<sup><font size="2">1</font></sup> Chang Yu,<sup><font size="2">1</font></sup> Fang Liang,<font size="2"><sup>1,</sup><sup>7</sup></font> Wenjie Li,<sup><font size="2">1</font></sup> Shaochuan Li,<sup><font size="2">1</font></sup> Dawei Li,<sup><font size="2">1</font></sup> Peixiang Ni,<sup><font size="2">1</font></sup> Jue Ruan,<font size="2"><sup>1,</sup><sup>7</sup></font> Qibin Li,<font size="2"><sup>1,</sup><sup>7</sup></font> Hongmei Zhu,<sup><font size="2">1</font></sup> Dongyuan Liu,<sup><font size="2">1</font></sup> Zhike Lu,<sup><font size="2">1</font></sup> Ning Li,<font size="2"><sup>1,</sup><sup>7</sup></font> Guangwu Guo,<font size="2"><sup>1,</sup><sup>7</sup></font> Jianguo Zhang,<sup><font size="2">1</font></sup> Jia Ye,<sup><font size="2">1</font></sup> Lin Fang,<sup><font size="2">1</font></sup> Qin Hao,<font size="2"><sup>1,</sup><sup>7</sup></font> Quan Chen,<font size="2"><sup>1,</sup><sup>5</sup></font> Yu Liang,<font size="2"><sup>1,</sup><sup>7</sup></font> Yeyang Su,<font size="2"><sup>1,</sup><sup>7</sup></font> A. san,<font size="2"><sup>1,</sup><sup>7</sup></font> Cuo Ping,<font size="2"><sup>1,</sup><sup>7</sup></font> Shuang Yang,<sup><font size="2">1</font></sup> Fang Chen,<font size="2"><sup>1,</sup><sup>7</sup></font> Li Li,<sup><font size="2">1</font></sup> Ke Zhou,<sup><font size="2">1</font></sup> Hongkun Zheng,<font size="2"><sup>1,</sup><sup>4</sup></font> Yuanyuan Ren,<sup><font size="2">1</font></sup> Ling Yang,<sup><font size="2">1</font></sup> Yang Gao,<font size="2"><sup>1,</sup><sup>6</sup></font> Guohua Yang,<font size="2"><sup>1,</sup><sup>2</sup></font> Zhuo Li,<sup><font size="2">1</font></sup> Xiaoli Feng,<sup><font size="2">1</font></sup> Karsten Kristiansen,<sup><font size="2">4</font></sup> Gane Ka-Shu Wong,<font size="2"><sup>1,</sup><sup>10</sup></font> Rasmus Nielsen,<sup><font size="2">9</font></sup> Richard Durbin,<sup><font size="2">8</font></sup> Lars Bolund,<font size="2"><sup>1,</sup><sup>11</sup></font> Xiuqing Zhang,<font size="2"><sup>1,</sup><sup>6</sup></font> Songgang Li,<font size="2"><sup>1,</sup><sup>2,</sup><sup>5</sup></font> Huanming Yang,<font size="2"><sup>1,</sup><sup>2,</sup><sup>3</sup></font> and Jian Wang<font size="2"><sup>1,</sup><sup>2,</sup><sup>3</sup></font></div>
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1Beijing Genomics Institute at Shenzhen, Shenzhen 518000, China.<br />
<div class="fm-affl"><sup><font size="2">1</font></sup>Beijing Genomics Institute at Shenzhen, Shenzhen 518000, China.</div>
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2Genome Research Institute, Shenzhen University Medical School, Shenzhen 518000, China.<br />
<div class="fm-affl"><sup><font size="2">2</font></sup>Genome Research Institute, Shenzhen University Medical School, Shenzhen 518000, China.</div>
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3National Engineering Center for Genomics and Bioinformatics, Beijing 101300, China.<br />
<div class="fm-affl"><sup><font size="2">3</font></sup>National Engineering Center for Genomics and Bioinformatics, Beijing 101300, China.</div>
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4Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M DK-5230, Denmark.<br />
<div class="fm-affl"><sup><font size="2">4</font></sup>Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M DK-5230, Denmark.</div>
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5College of Life Sciences, Peking University, Beijing 100871, China.<br />
<div class="fm-affl"><sup><font size="2">5</font></sup>College of Life Sciences, Peking University, Beijing 100871, China.</div>
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6Beijing Genomics Institute, Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing 101300, China.<br />
<div class="fm-affl"><sup><font size="2">6</font></sup>Beijing Genomics Institute, Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing 101300, China.</div>
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7The Graduate University of Chinese Academy of Sciences, Beijing 100062, China.<br />
<div class="fm-affl"><sup><font size="2">7</font></sup>The Graduate University of Chinese Academy of Sciences, Beijing 100062, China.</div>
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8The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.<br />
<div class="fm-affl"><sup><font size="2">8</font></sup>The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.</div>
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9Departments of Integrative Biology and Statistics, University of California, Berkeley, California 94720, USA.<br />
<div class="fm-affl"><sup><font size="2">9</font></sup>Departments of Integrative Biology and Statistics, University of California, Berkeley, California 94720, USA.</div>
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10Department of Biological Sciences and Department of Medicine, University of Alberta, Edmonton AB, T6G 2E9, Canada.<br />
<div class="fm-affl"><sup><font size="2">10</font></sup>Department of Biological Sciences and Department of Medicine, University of Alberta, Edmonton AB, T6G 2E9, Canada.</div>
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11Insitute of Human Genetics, University of Aarhus, Aarhus DK-8000, Denmark.<br />
<div class="fm-affl"><sup><font size="2">11</font></sup>Insitute of Human Genetics, University of Aarhus, Aarhus DK-8000, Denmark.</div>
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Correspondence and requests for materials should be addressed to Ju.W. (Email: wangj@genomics.org.cn ) or Ji.W. (Email: wangjian@genomics.org.cn ).<br />
<div id="CR1" class="fm-footnote">Correspondence and requests for materials should be addressed to Ju.W. (<span class="email-label">Email: </span><span class="e_id4088377"><a class="ext-reflink" href="mailto:wangj@genomics.org.cn" _sg="true">wangj@genomics.org.cn</a></span>
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*These authors contributed equally to this work.<br />
<script language="JavaScript" type="text/javascript"><!--
+
Author Contributions Ju.W., W.W., R.L. and Yi.L. contributed equally to this work. Ju.W., H.Y. and Ji.W. managed the project. W.W., G.T., Jun.Z., Jua.Z., Ya.L., Hu.L., Yi.Z., Zhenz.Y., X.Y., B.Y., W.L., Da.L., Q.H., Yu.L., S.Y., F.C., L.L., K.Z., Y.R., L.Y., Y.G., G.Y., Zhu.L., Xiaol.F., K.K., L.B. and X.Z. performed sequencing. Ju.W., R.L. and Yi.L. designed the analyses. R.L., Yi.L., W.F., J.L., Y.G., B.F., He.L., Xiaod.F., Z.D., Dong Li, Y.H., H.Z., I.H., M.I., J.P., Jin.Z., J.D., Ya.Z., J.Q., L.M., G.L., Zhent.Y., G.Z., C.Y., F.L, S.L, P.N., J.R., Q.L., Hongm.Z., Dongy.L, Zhi.L., N.L., G.G., Jia.Z., J.Y., L.F., Q.C., Y.S., A S., C.P., Hongk.Z., G.W., R.N., R.D. and S.L. performed the data analyses. Ju.W., R.L., Yi.L. and L.G. wrote the paper.<br />
                                    try{initUnObscureEmail ("e_id4088377", '<a class="ext-reflink" href="' + reverseAndReplaceString('nc.gro.scimoneg/ta/jgnaw:otliam', '/at/', '@') + '">' + reverseAndReplaceString('nc.gro.scimoneg/ta/jgnaw', '/at/','@') + '</a>')}catch(e){}
+
Author Information The data have been deposited in the EBI/NCBI short read archive (accession number ERA000005). These data, together with all the associated analyses, are freely availably at http://yh.genomics.org.cn. SNPs and indels have been submitted to NCBI dbSNP and will be available in dbSNP version 130. Reprints and permissions information is available at www.nature.com/reprints. This paper is distributed under the terms of the Creative Commons Attribution-Non-Commercial-Share Alike licence, and is freely available to all readers at www.nature.com/nature.</p>
                                //--></script>
 
) or Ji.W. (<span class="email-label">Email: </span><span class="e_id4088381"><a class="ext-reflink" href="mailto:wangjian@genomics.org.cn" _sg="true">wangjian@genomics.org.cn</a></span>
 
<script language="JavaScript" type="text/javascript"><!--
 
                                    try{initUnObscureEmail ("e_id4088381", '<a class="ext-reflink" href="' + reverseAndReplaceString('nc.gro.scimoneg/ta/naijgnaw:otliam', '/at/', '@') + '">' + reverseAndReplaceString('nc.gro.scimoneg/ta/naijgnaw', '/at/','@') + '</a>')}catch(e){}
 
                                //--></script>
 
).</div>
 
<div id="FN1" class="fm-footnote"><sup><font size="2">*</font></sup>These authors contributed equally to this work.</div>
 
<div id="FN2" class="fm-footnote">
 
<div id="P2" class="p p-first-last"><strong>Author Contributions</strong> Ju.W., W.W., R.L. and Yi.L. contributed equally to this work. Ju.W., H.Y. and Ji.W. managed the project. W.W., G.T., Jun.Z., Jua.Z., Ya.L., Hu.L., Yi.Z., Zhenz.Y., X.Y., B.Y., W.L., Da.L., Q.H., Yu.L., S.Y., F.C., L.L., K.Z., Y.R., L.Y., Y.G., G.Y., Zhu.L., Xiaol.F., K.K., L.B. and X.Z. performed sequencing. Ju.W., R.L. and Yi.L. designed the analyses. R.L., Yi.L., W.F., J.L., Y.G., B.F., He.L., Xiaod.F., Z.D., Dong Li, Y.H., H.Z., I.H., M.I., J.P., Jin.Z., J.D., Ya.Z., J.Q., L.M., G.L., Zhent.Y., G.Z., C.Y., F.L, S.L, P.N., J.R., Q.L., Hongm.Z., Dongy.L, Zhi.L., N.L., G.G., Jia.Z., J.Y., L.F., Q.C., Y.S., A S., C.P., Hongk.Z., G.W., R.N., R.D. and S.L. performed the data analyses. Ju.W., R.L., Yi.L. and L.G. wrote the paper.</div>
 
</div>
 
<div id="FN3" class="fm-footnote">
 
<div id="P3" class="p p-first-last"><strong>Author Information</strong> The data have been deposited in the EBI/NCBI short read archive (accession number ERA000005). These data, together with all the associated analyses, are freely availably at <span class="ext-reflink"><a class="ext-reflink " href="http://yh.genomics.org.cn" target="pmc_ext" _sg="true" ref="reftype=extlink&amp;article-id=2716080&amp;issue-id=180413&amp;journal-id=358&amp;FROM=Article%7CFront%20Matter&amp;TO=External%7CLink%7CURI&amp;rendering-type=nihms">http://yh.genomics.org.cn</a></span>. SNPs and indels have been submitted to NCBI dbSNP and will be available in dbSNP version 130. Reprints and permissions information is available at <span class="ext-reflink"><a class="ext-reflink " href="http://www.nature.com/reprints" target="pmc_ext" _sg="true" ref="reftype=extlink&amp;article-id=2716080&amp;issue-id=180413&amp;journal-id=358&amp;FROM=Article%7CFront%20Matter&amp;TO=External%7CLink%7CURI&amp;rendering-type=nihms">www.nature.com/reprints</a></span>. This paper is distributed under the terms of the Creative Commons Attribution-Non-Commercial-Share Alike licence, and is freely available to all readers at <span class="ext-reflink"><a class="ext-reflink " href="http://www.nature.com/nature" target="pmc_ext" _sg="true" ref="reftype=extlink&amp;article-id=2716080&amp;issue-id=180413&amp;journal-id=358&amp;FROM=Article%7CFront%20Matter&amp;TO=External%7CLink%7CURI&amp;rendering-type=nihms">www.nature.com/nature</a></span>.</div>
 
</div>
 
</span></p>
 

Latest revision as of 23:38, 15 January 2011

 Nature. 2008 Nov 6;456(7218):60-5.

 


The diploid genome sequence of an Asian individual

 


Jun Wang,1,2,3,4* Wei Wang,1,3* Ruiqiang Li,1,3,4* Yingrui Li,1,5,6* Geng Tian,1,7 Laurie Goodman,1 Wei Fan,1 Junqing Zhang,1 Jun Li,1 Juanbin Zhang,1 Yiran Guo,1,7 Binxiao Feng,1 Heng Li,1,8 Yao Lu,1 Xiaodong Fang,1 Huiqing Liang,1 Zhenglin Du,1 Dong Li,1 Yiqing Zhao,1,7 Yujie Hu,1,7 Zhenzhen Yang,1 Hancheng Zheng,1 Ines Hellmann,9 Michael Inouye,8 John Pool,9 Xin Yi,1,7 Jing Zhao,1 Jinjie Duan,1 Yan Zhou,1 Junjie Qin,1,7 Lijia Ma,1,7 Guoqing Li,1 Zhentao Yang,1 Guojie Zhang,1,7 Bin Yang,1 Chang Yu,1 Fang Liang,1,7 Wenjie Li,1 Shaochuan Li,1 Dawei Li,1 Peixiang Ni,1 Jue Ruan,1,7 Qibin Li,1,7 Hongmei Zhu,1 Dongyuan Liu,1 Zhike Lu,1 Ning Li,1,7 Guangwu Guo,1,7 Jianguo Zhang,1 Jia Ye,1 Lin Fang,1 Qin Hao,1,7 Quan Chen,1,5 Yu Liang,1,7 Yeyang Su,1,7 A. san,1,7 Cuo Ping,1,7 Shuang Yang,1 Fang Chen,1,7 Li Li,1 Ke Zhou,1 Hongkun Zheng,1,4 Yuanyuan Ren,1 Ling Yang,1 Yang Gao,1,6 Guohua Yang,1,2 Zhuo Li,1 Xiaoli Feng,1 Karsten Kristiansen,4 Gane Ka-Shu Wong,1,10 Rasmus Nielsen,9 Richard Durbin,8 Lars Bolund,1,11 Xiuqing Zhang,1,6 Songgang Li,1,2,5 Huanming Yang,1,2,3 and Jian Wang1,2,3
1Beijing Genomics Institute at Shenzhen, Shenzhen 518000, China.
2Genome Research Institute, Shenzhen University Medical School, Shenzhen 518000, China.
3National Engineering Center for Genomics and Bioinformatics, Beijing 101300, China.
4Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M DK-5230, Denmark.
5College of Life Sciences, Peking University, Beijing 100871, China.
6Beijing Genomics Institute, Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing 101300, China.
7The Graduate University of Chinese Academy of Sciences, Beijing 100062, China.
8The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
9Departments of Integrative Biology and Statistics, University of California, Berkeley, California 94720, USA.
10Department of Biological Sciences and Department of Medicine, University of Alberta, Edmonton AB, T6G 2E9, Canada.
11Insitute of Human Genetics, University of Aarhus, Aarhus DK-8000, Denmark.
Correspondence and requests for materials should be addressed to Ju.W. (Email: wangj@genomics.org.cn ) or Ji.W. (Email: wangjian@genomics.org.cn ).

  • These authors contributed equally to this work.

Author Contributions Ju.W., W.W., R.L. and Yi.L. contributed equally to this work. Ju.W., H.Y. and Ji.W. managed the project. W.W., G.T., Jun.Z., Jua.Z., Ya.L., Hu.L., Yi.Z., Zhenz.Y., X.Y., B.Y., W.L., Da.L., Q.H., Yu.L., S.Y., F.C., L.L., K.Z., Y.R., L.Y., Y.G., G.Y., Zhu.L., Xiaol.F., K.K., L.B. and X.Z. performed sequencing. Ju.W., R.L. and Yi.L. designed the analyses. R.L., Yi.L., W.F., J.L., Y.G., B.F., He.L., Xiaod.F., Z.D., Dong Li, Y.H., H.Z., I.H., M.I., J.P., Jin.Z., J.D., Ya.Z., J.Q., L.M., G.L., Zhent.Y., G.Z., C.Y., F.L, S.L, P.N., J.R., Q.L., Hongm.Z., Dongy.L, Zhi.L., N.L., G.G., Jia.Z., J.Y., L.F., Q.C., Y.S., A S., C.P., Hongk.Z., G.W., R.N., R.D. and S.L. performed the data analyses. Ju.W., R.L., Yi.L. and L.G. wrote the paper.
Author Information The data have been deposited in the EBI/NCBI short read archive (accession number ERA000005). These data, together with all the associated analyses, are freely availably at http://yh.genomics.org.cn. SNPs and indels have been submitted to NCBI dbSNP and will be available in dbSNP version 130. Reprints and permissions information is available at www.nature.com/reprints. This paper is distributed under the terms of the Creative Commons Attribution-Non-Commercial-Share Alike licence, and is freely available to all readers at www.nature.com/nature.