Restless legs syndrome - Revision history

WikiSysop at 05:59, 2 January 2008

2008-01-02T05:59:38Z

WikiSysop at 05:59, 2 January 2008

2008-01-02T05:59:13Z

WikiSysop at 05:58, 2 January 2008

2008-01-02T05:58:46Z

Thkim at 15:36, 27 December 2007

2007-12-27T15:36:57Z

Thkim at 15:33, 27 December 2007

2007-12-27T15:33:28Z

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GENE: RLS1 
CYTO: 12q12-q21 
DESC: Restless legs syndrome, susceptibility to, 1 
SNP : rs2300478 
 
In a genomewide association study of 393 RLS patients and 1602 controls, 
Winkelmann et al. (2007) found a significant association between RLS and 
dbSNP rs2300478 in the MEIS1 gene (601739). The findings were confirmed 
in 2 independent replication studies of 875 and 211 patients, 
respectively. Combined results of all 3 studies yielded an overall odds 
ratio of 1.74 for the G allele (p = 8.08 x 10(-23)). The study also 
showed evidence for an association with several SNPs within a region on 
chromosome 15q that contains the LBXCOR1 (611273) and MAP2K5 (602520) 
genes. 
 
Reference 
Winkelmann, J.; Schormair, B.; Lichtner, P.; Ripke, S.; Xiong, L.; Jalilzadeh, S.; Fulda, S.; Putz, B.; Eckstein, G.; Hauk, S.; Trenkwalder, C.; Zimprich, A.; and 15 others : 
:Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nature Genet. 39: 1000-1006, 2007. PubMed ID : 17637780

@@ Line 1: / Line 1: @@
 <strong><font size="4">Study</font></strong><br />
 In a genomewide association study of 393 RLS patients and 1602 controls, Winkelmann et al. (2007) found a significant association between [[restless legs syndrome]] and dbSNP rs2300478 in the MEIS1 gene (601739). The findings were confirmed in 2 independent replication studies of 875 and 211 patients, respectively. Combined results of all 3 studies yielded an overall odds ratio of 1.74 for the G allele (p = 8.08 x 10(-23)). The study also showed evidence for an association with several SNPs within a region on chromosome 15q that contains the LBXCOR1 (611273) and MAP2K5 (602520) genes.<br />
 <br />
 <font size="4"><strong>Other information</strong></font><br />

@@ Line 1: / Line 1: @@
 <strong><font size="4">Study</font></strong><br />
-In a genomewide association study of 393 RLS patients and 1602 controls, Winkelmann et al. (2007) found a significant association between RLS and dbSNP rs2300478 in the MEIS1 gene (601739). The findings were confirmed in 2 independent replication studies of 875 and 211 patients, respectively. Combined results of all 3 studies yielded an overall odds ratio of 1.74 for the G allele (p = 8.08 x 10(-23)). The study also showed evidence for an association with several SNPs within a region on chromosome 15q that contains the LBXCOR1 (611273) and MAP2K5 (602520) genes.<br />
+In a genomewide association study of 393 RLS patients and 1602 controls, Winkelmann et al. (2007) found a significant association between [[restless legs syndrome]] and dbSNP rs2300478 in the MEIS1 gene (601739). The findings were confirmed in 2 independent replication studies of 875 and 211 patients, respectively. Combined results of all 3 studies yielded an overall odds ratio of 1.74 for the G allele (p = 8.08 x 10(-23)). The study also showed evidence for an association with several SNPs within a region on chromosome 15q that contains the LBXCOR1 (611273) and MAP2K5 (602520) genes.<br />
 <br />
 <font size="4"><strong>Other information</strong></font><br />

@@ Line 7: / Line 7: @@
 DESC: Restless legs syndrome, susceptibility to, 1<br />
 SNP&nbsp;&nbsp; : rs2300478<br />
 <br />
 <font size="4"><strong>Reference</strong></font><br />
 Winkelmann, J.; Schormair, B.; Lichtner, P.; Ripke, S.; Xiong, L.; Jalilzadeh, S.; Fulda, S.; Putz, B.; Eckstein, G.; Hauk, S.; Trenkwalder, C.; Zimprich, A.; and 15 others : <br />
 :Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nature Genet. 39: 1000-1006, 2007. PubMed ID : 17637780<br />

@@ Line 1: / Line 1: @@
 GENE: RLS1<br />
-CYTO: 12q12-q21<br />
+CYTO : 12q12-q21<br />
 DESC: Restless legs syndrome, susceptibility to, 1<br />
-SNP : rs2300478<br />
+SNP&nbsp;&nbsp; : rs2300478<br />
 <br />
-<font size="4">Reference</font><br />
+<font size="4"><strong>Reference</strong></font><br />
 Winkelmann, J.; Schormair, B.; Lichtner, P.; Ripke, S.; Xiong, L.; Jalilzadeh, S.; Fulda, S.; Putz, B.; Eckstein, G.; Hauk, S.; Trenkwalder, C.; Zimprich, A.; and 15 others : <br />
 :Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nature Genet. 39: 1000-1006, 2007. PubMed ID : 17637780<br />